NSI-189 Phosphate

Description

NSI-189 Phosphate, Powder

NSI-189 Phosphate is a derivative of NSI-189 Free Base, a synthetic compound developed for its neurogenic and nootropic properties. It was originally synthesized to treat major depressive disorder (MDD) and cognitive impairments by stimulating the growth of new neurons (neurogenesis) in the hippocampus, a brain region associated with memory, learning, and mood regulation. The phosphate form is more stable and easier to work with than the free base.

Studies suggest that NSI-189 Phosphate may help alleviate symptoms of depression, improve cognitive function, and enhance overall brain health by increasing hippocampal volume and promoting the regeneration of brain cells. Additionally, it has been shown to enhance mood and support cognitive resilience in stressful or depressive conditions.

Mechanism of Action:

NSI-189 Phosphate works primarily by promoting neurogenesis in the hippocampus, the region of the brain responsible for memory formation and mood regulation. This is crucial because hippocampal volume tends to shrink in individuals with depression or cognitive decline, contributing to symptoms such as memory loss and mood disorders.

• Hippocampal Neurogenesis: Studies like Zhao et al. (2012) have demonstrated that NSI-189 significantly increases hippocampal volume by stimulating the production of new neurons. This helps restore brain function and cognitive health.
• Antidepressant Effects: The compound’s ability to regenerate neurons in the hippocampus suggests that NSI-189 may be particularly effective in treating depression. Research shows that it could improve mood and alleviate symptoms of depression by restoring healthy brain function.

Benefits:

• Memory and Cognitive Function: NSI-189 Phosphate enhances memory, learning, and cognitive function by promoting neurogenesis and synaptic plasticity in the hippocampus.
• Mood Improvement: By increasing hippocampal volume and regenerating neurons, NSI189 Phosphate has the potential to improve mood and reduce symptoms of depression. This effect may be particularly beneficial for individuals with treatment-resistant depression.
• Neuroprotection: NSI-189 Phosphate may protect against age-related cognitive decline and neurodegenerative diseases by promoting brain cell regeneration and neuroplasticity.
• Stress Resilience: It enhances cognitive and emotional resilience, particularly in conditions of stress or depression, by supporting brain health and function. 

Clinical Research:

• Neurogenesis and Cognitive Function: A study by Zhao et al. (2012) showed that NSI189 Phosphate increased neurogenesis in the hippocampus and improved cognitive function in animal models. The study suggested potential therapeutic applications for cognitive impairments and neurodegenerative conditions.
• Depression and Mood: In a Phase I/II clinical trial by Neuralstem Inc. (2015), NSI 189 Phosphate was found to improve mood and cognitive performance in patients with major depressive disorder (MDD). Participants reported significant mood improvements and better cognitive function after treatment.

Additional Effects:

• Improved Learning Capacity: By enhancing synaptic plasticity and promoting neurogenesis, NSI-189 -Phos’phate supports the brain’s ability to learn and retain new information.
• Potential Therapeutic Use for Neurodegenerative Diseases: Its ability to promote neurogenesis suggests that NSI-189 Phosphate may have applications in treating neurodegenerative conditions like Alzheimer’s disease, though further research is needed.

Key Differences Between NSI-189 Phosphate and NSI-189 Free Base:

• Solubility: The addition of the phosphate group increases the water solubility of NSI-189 Phos’phate, making it easier for the body to absorb and process compared to the free base. This means the phosphate version may dissolve more readily in water, leading to better bioavailability.
• Stability: NSI-189 Phosphate is more chemically stable than the free base. This increased stability makes it easier to store and work with, providing a longer shelf life and more reliable performance in various formulations.
• Bioavailability: Due to its improved solubility, NSI -189 Phosphate may offer enhanced bioavailability, meaning it is absorbed more efficiently by the body.

For detailed lab analysis and product specifications, please refer to the next tabs.