Picamilon Sodium
From €23.40
Picamilon is a nootropic compound that combines niacin (vitamin B3) and GABA, known for its ability to improve mood, reduce anxiety, and enhance cognitive function. It crosses the blood-brain barrier effectively, delivering calming effects without sedation, while also boosting mental clarity and energy.
For a more detailed description and lab analysis, please see the sections below.
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Description
Picamilon sodium, Powder
Picamilon is a unique nootropic created by combining niacin (a vasodilator) and GABA (a neurotransmitter that promotes relaxation). This combination allows Picamilon to cross the blood-brain barrier, where it delivers both GABA for its calming effects and niacin to improve blood flow in the brain. It is used for its ability to reduce anxiety and stress without causing drowsiness, while also promoting mental clarity and cognitive performance.
Picamilon enhances cerebral blood flow due to the niacin component, which expands blood vessels in the brain, resulting in increased oxygen and nutrient delivery. Meanwhile, GABA works to calm the nervous system by promoting inhibitory neurotransmission, making it effective for reducing anxiety, improving mood, and supporting cognitive function.
Mechanism of Action:
Picamilon works by allowing the niacin-GABA compound to cross the blood-brain barrier, where it is broken down into its two components: niacin and GABA. Once in the brain:
- Niacin acts as a vasodilator, improving blood flow to the brain, leading to enhanced mental clarity, focus, and energy.
- GABA functions as an inhibitory neurotransmitter, helping to reduce neural excitability and inducing a calming effect. This can reduce anxiety and stress without causing drowsiness or sedation.
Benefits:
- Anxiety and Stress Reduction: The GABA component of Picamilon provides a calming effect, reducing symptoms of anxiety and stress while maintaining mental clarity and focus.
- Improved Cognitive Function: By increasing blood flow to the brain, the niacin component supports improved cognitive performance, focus, and mental clarity.
- Mood Enhancement: Many users report a better mood and a sense of mental well-being, thanks to the combination of relaxation from GABA and enhanced brain function from niacin.
- Non-Sedative Calming Effect: Unlike many GABAergic compounds, Picamilon provides relaxation without the sedative effects, making it ideal for those looking to reduce anxiety while staying alert and focused.
Clinical Research:
- Anxiety Reduction: A study by Lapin (1999) found that Picamilon significantly reduced anxiety and improved mood in individuals with mild anxiety. The combination of GABA and niacin was particularly effective in providing calming effects without cognitive impairment.
- Improved Cerebral Blood Flow: Research conducted by Babushkina et al. (1998) demonstrated that Picamilon enhances cerebral blood flow in patients with cerebrovascular insufficiency, suggesting its potential in improving cognitive function and mental performance.
Additional Effects:
- Neuroprotection: Picamilon may have neuroprotective properties by improving blood flow to the brain and reducing oxidative stress. This could help protect against age-related cognitive decline and neurodegenerative diseases.
- Physical Stamina: Anecdotal reports suggest that Picamilon may also improve physical stamina and reduce fatigue, likely due to increased cerebral oxygenation and nutrient delivery.
For a detailed lab analysis and comprehensive product specifications, please refer to the next tabs.
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Lab Analysis
Picamilon Sodium CoA LOT : 231122
2211EURO.163B Picamilon Sodium_CoA Lot=181022
2211EURO.163B_Picamilon Sodium CAS= 34562-97-5 Lot=181022 (HNMR)
Chemical Informations
| Technical Information | |
|---|---|
| CAS Number | 62936-56-5 |
| PubChem CID | 23663986 |
| Purity | ≥98% |
| Molecular Weight | 230.20 g/mol |
| Molecular Formula | C₁₀H₁₁N₂O₃ •Na |
| Melting Point | 208.0-212.0°C |
| Synonyms | Picamilon, Pikamilone sodium salt, Pikamilone, Pikamilon sodium salt, Nicotinoyl-GABA sodium salt, 4-(Pyridine-3-carbonylamino)butanoic acid sodium salt, Monosodium 4-(pyridine-3-carbonylamino)butanoate, Monosodium 4-Nicotinoylaminobutyrate, N-(3-Pyridinylcarbonyl)-4-aminobutyric acid sodium |
| SMILES Notation | C1=CC(=CN=C1)C(=O)NCCCC(=O)[O-].[Na+] |
| Application | Picamilon is a linked derivative of the vitamin Niacin (vitamin B3, nicotinic acid) with the inhibitory neurotransmitter GABA, useful in the research of BBB penetrant molecules which hydrolyze to yield GABA. |
| Appearance | White or off-white powder |
| Physical State | Solid |
| Solubility | – Freely soluble in Ethanol – Freely soluble in Water |
| Storage Conditions | Store at room temperature or cooler, in a sealed airtight container, protected from heat, light, and humidity. |
| Stability | Stable for at least two years when stored as above. |
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