Description
4′-DMA-7,8-DHF is a modified version of 7,8-DHF, a naturally occurring flavonoid that acts as a potent TrkB receptor agonist. The TrkB receptor is the primary receptor for BDNF, a critical protein involved in neuron survival, synaptic plasticity, and memory formation. By activating TrkB receptors, 4′-DMA-7,8-DHF has shown potential to promote brain health, support memory, and enhance learning capabilities.
The dimethylamino group attached to the 4′ position of the molecule enhances its solubility and bioavailability compared to 7,8-DHF, making it more effective in crossing the blood-brain barrier and activating the TrkB pathway.
Mechanism of Action:
4′- DMA-7,8 -DHF works by directly activating TrkB receptors, which play a key role in neuroplasticity and cognitive function:
- TrkB Receptor Activation: By binding to and activating the TrkB receptor, 4′-DMA-7,8-DHF stimulates pathways involved in neuron growth, survival, and synaptic communication.
- BDNF Mimetic: As a BDNF mimetic, it replicates the actions of BDNF, supporting the processes that lead to memory formation, learning, and neuroprotection.
Effects:
- Neuroprotection: 4′-DMA-7,8-DHF helps protect neurons from oxidative stress and excitotoxicity, making it a candidate for neurodegenerative disease treatment.
- Cognitive Enhancement: By promoting synaptic plasticity and neurogenesis, 4′-DMA-7,8-DHF may improve memory, learning, and overall cognitive function.
- Mood Support: The activation of TrkB receptors may help regulate mood and reduce symptoms of anxiety and depression, as BDNF is closely linked to mood stabilization.
Clinical Research:
- Neuroplasticity and Cognitive Function: Research on 7 ,8- D HF and its derivatives, including 4′-D MA-7,8-DHF, has shown significant potential in enhancing neuroplasticity, promoting synaptic growth, and improving memory performance in animal models.
- Neuroprotection in Neurodegenerative Diseases: Studies suggest that 7,8-DHF and its analogs offer protection against neurodegenerative conditions like Alzheimer’s and Parkinson’s by reducing oxidative stress and supporting neuron survival.
Additional Effects:
- Support for Learning: 4′-D MA-7,8-DHF’s influence on TrkB receptors may facilitate learning processes, helping improve cognitive flexibility and adaptability.
- Potential in Age-Related Cognitive Decline: The compound’s neuroprotective properties may offer potential in slowing cognitive decline related to aging or neurodegeneration.
For detailed lab analysis and product specifications, please refer to the next tabs.