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NSI-189 Free Base – Solution


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NSI-189 Free Base, Solution 1200mg (40mg/mL)

NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo. Emerging evidence also indicates that NSI-189 phosphate has regionally specific effects insofar as neurogenesis is observed largely in the subventricular zone of the hippocampus. Results from a preliminary proof of concept study suggests that NSI-189 may be capable of mitigating depressive symptoms and improve cognitive function in adults with DSM-5-defined Major Depressive Disorder (MDD).

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This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

Chemical Informations

Application Selective glucocorticoid receptor agonist
CAS 1270138-40-3
Molar Mass 366.5 g/mol
Chemical Formula C22H30N4O
IUPAC Name (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone
Synonyms NSI-189, NSI189, NSI 189
Storage Store at room temperature. Keep the container tightly sealed, away from heat, light and moisture.
Solubility Soluble in Ethanol
Organoleptic Profile Clear liquid
Physical Form Liquid, solved in Ethanol
Specification 40mg/mL ±10%