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NSI-189 Free Base

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NSI-189 Free Base, Powder

NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo. Emerging evidence also indicates that NSI-189 phosphate has regionally specific effects insofar as neurogenesis is observed largely in the subventricular zone of the hippocampus. Results from a preliminary proof of concept study suggests that NSI-189 may be capable of mitigating depressive symptoms and improve cognitive function in adults with DSM-5-defined Major Depressive Disorder (MDD).

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Additional information


1g, 5g

Chemical Informations

Application TBA
CAS 1270138-40-3
Molar Mass 366.4998 g/mol
 Chemical Formula C22H30N4O1
IUPAC Name (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone
Synonyms NSI-189, NSI189, NSI 189
Storage Room temperature
Solubility Soluble in Ethanol
Organoleptic Profile White crystalline powder
Physical Form Solid
Specification ≥98%

Lab Analysis

23-EMA-1_P10_coa_m0_NSI 189 Free base
2301EURO.634C_NSI189 FB cas= 1270138-40-3 LOT=180223
2310EURO.923B_NSI 189 FREE BASE LOT= 231122