Neuroprotection refers to the aim of preserving neuron function and structure in response to a CNS-insult (acute injury or chronic disease). Neuroprotective agents aim to offer a form of protection against neuronal injury or the degeneration of neurons caused by diseases like Parkinson’s, Alzheimer’s, or Multiple Sclerosis.
An important aspect of neuroprotective substances involves the management of secondary brain injury, as a result of the initial CNS insult. This can be the result of traumatic brain injury or acute neurotoxicity (for example, methamphetamine overdose), or the result of chronic degenerative diseases. Secondary brain injury refers to the changes that occur in the brain as a result of an initial CNS injury.