Fasoracetam
From €22.80
Fasoracetam is a new and promising racetam nootropic compound, known for its potential to enhance memory, learning, and cognitive function. It is also recognized for its ability to modulate neurotransmitter systems like acetylcholine, GABA, and glutamate, which are essential for cognitive processes, mood regulation, and mental clarity.
For a more detailed description and lab analysis, please see the sections below.
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Description
Fasoracetam, Powder
Fasoracetam is the newest member of the racetam family of nootropics that is currently being developed as a potential non-stimulant ADHD treatment. In terms of comparison to other racetam compounds, this compound is much newer than most, having only been developed in the late 1980s. It also made it a lot further than many racetams in terms of its research and development (having got to phase III clinical trials for dementia). In terms of its physiological effects, it is the one of the only racetam compounds to act on mGluRs, offering potentially unique benefits in a research setting. It is also the one of the only racetams to regulate GABA signaling, acting as an antagonist in acute administration, but upregulating signals when administered over time.
Fasoracetam works by influencing several key neurotransmitter systems in the brain:
- Acetylcholine: Fasoracetam increases acetylcholine release, which plays a crucial role in memory formation and learning.
- GABA (Gamma-Aminobutyric Acid): Fasoracetam upregulates GABA receptors, contributing to its potential anti-anxiety effects, mood stabilization, and relaxation without causing sedation.
- Glutamate: The compound also modulates the activity of metabotropic glutamate receptors (mGluRs), which are involved in synaptic plasticity, learning, and memory processes.
Mechanism of Action:
Fasoracetam exerts its cognitive-enhancing effects through modulation of multiple neurotransmitter systems:
- Acetylcholine Modulation: By increasing the release of acetylcholine, Fasoracetam supports memory and learning processes, particularly in the hippocampus, the region of the brain associated with these functions.
- GABA Receptor Upregulation: Fasoracetam has been shown to upregulate GABA-B receptors, which may contribute to reducing anxiety, enhancing mood, and promoting mental calmness without causing drowsiness.
- Glutamate Modulation: Fasoracetam regulates the activity of mGluRs, which are critical for synaptic plasticity and cognitive flexibility. This may improve the brain’s ability to adapt and process new information.
Effects:
- Enhanced Memory and Learning: Fasoracetam is believed to improve both short-term and long-term memory by boosting acetylcholine release and supporting synaptic plasticity, making it easier to learn and retain new information.
- Focus and Mental Clarity: The compound may enhance focus and mental clarity by modulating neurotransmitter systems involved in attention and cognitive processing.
- Mood and Anxiety Support: Its effects on GABA receptors may help regulate mood and reduce anxiety, promoting a calm yet alert mental state without causing sedation.
- Neuroprotective Properties: Its modulation of neurotransmitter systems may provide protective effects against cognitive decline by supporting neuronal health and reducing excitotoxicity (damage caused by overstimulation of neurons).
Clinical Research:
- Memory and Cognitive Function: Research by Helmeste et al. (1996) demonstrated Fasoracetam’s potential to improve memory performance in preclinical models, particularly in tasks requiring learning and memory retention.
- Anxiety and Mood Regulation: Studies on GABA modulation, such as those by Carnevale et al. (2011), suggest that Fasoracetam may have anxiolytic effects through GABA-B receptor upregulation, making it potentially useful for mood stabilization and reducing anxiety.
Additional Effects:
- Cognitive Flexibility: Fasoracetam’s influence on glutamate receptors may enhance cognitive flexibility, allowing for better adaptation to new information and improved problem-solving skills.
- Potential Use in ADHD: Fasoracetam has been studied for its potential application in treating attention deficit hyperactivity disorder (ADHD) due to its modulation of neurotransmitter systems involved in attention and focus.
Safety and Considerations:
Fasoracetam is generally well-tolerated, with few reported side effects. Mild side effects may include headaches, fatigue, or gastrointestinal discomfort. As with other racetams, it may be beneficial to pair Fasoracetam with a choline supplement to support acetylcholine production and minimize headaches.
For detailed lab analysis and product specifications, please refer to the sections below.
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Chemical Informations
| Technical Information | |
|---|---|
| CAS Number | 110958-19-5 |
| PubChem CID | 198695 |
| Purity | ≥98% |
| Molecular Weight | 196.25 g/mol |
| Molecular Formula | C₁₀H₁₆N₂O₂ |
| Melting Point | +57 °C |
| Synonyms | (5R)-5-oxo-D-prolinepiperidinamide monohydrate, NS-105, AEVI-001, LAM 105, MDGN-001, NFC 1, N-(5-Oxo-D-prolyl)piperidine, UNII-42O8UF5CJB, (R)-1-((5-Oxo-2-pyrrolidinyl)carbonyl)piperidine |
| SMILES Notation | C1CCN(CC1)C(=O)C2CCC(=O)N2 |
| Application | Agonist of all three metabotropic glutamate receptors (mGluRs) with potential antidepressant action, used in clinical trials for vascular dementia and attention deficit disorder. |
| Appearance | White powder |
| Physical State | Solid |
| Solubility | Soluble in DMSO |
| Storage Conditions | Store in dry, dark conditions at 0 – 4 °C for short-term (weeks), and -20°C for long-term storage. |
| Stability | Stable for at least four years when stored unopened and desiccated at -20°C. |
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