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IDRA-21, Powder

IDRA-21 is a drug derived from the benzothiadiazine (not to be confused with benzodiazepine) chemical structure.

As it is a nootropic substance, IDRA-21 has been shown in a clinical setting to improve cognitive ability with little to no adverse effects. However, it is also important to point out that IDRA-21 is still a very new substance to the world, and still currently has more anecdotal evidence for efficacy compared to the amount of available lab research.

In a study done with patas monkeys, the experimenters measured the subjects’ cognitive performance in a complex behavioral task.  The monkeys were given the drug alprazolam before the task was given in order to induce a learning deficit (Thomas et al.)  The known nootropic drug aniracetam was pitted against IDRA-21 to test the latter’s efficacy in reversing impairment.

Results showed that the IDRA-21 was ten times as powerful as the aniracetam in terms of dosage, meaning that the effects were far more potent dose per dose.  The effects of IDRA-21 remained persistent for three days after a single dose, marking it as an extremely long-lasting nootropic especially when compared to the roughly 2 to 3 hour windows given by many other ampakines.


This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

Additional information


1g, 2g, 5g

Chemical Informations

Application Positive allosteric modulator of the AMPA receptor and a benzothiadiazine derivative
CAS 22503-72-6
Molar Mass 232.69 g/mol
Chemical Formula C8H9ClN2O2S
IUPAC Name 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
Synonyms 22503-72-6, Idra-21,7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide, 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide,7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide,163936-78-5, (+)-IDRA-21, (-)-IDRA-21, AC1L1GHQ, AC1Q3ORY, Biomol-NT_000225, CHEMBL77862, SCHEMBL195328, BPBio1_001088GTPL4219, CTK4E9603, AOB5944, DTXSID70936887, EX-A737, CHEBI:111162, HMS3267D13, HMS3412O19, HMS3676O19, BCP19065, KS-00000GF1, 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S dioxide, MFCD00270874, AKOS024456473, API0008958, FCH1331231, 2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, (+)-, 2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, (-)-, 7-chloro-3-methyl-3,4-dihydro-2H-1, NCGC00025050-02, 163936-79-6, AK326156, DS-11824, SC-90074, CS-0021632, FT-0700269, ST50825828, SR-01000597374, J-014742, SR-01000597374-1, BRD-A14344385-001-01-6, BRD-A14344385-001-02-4, 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine, 7-chloro-3-methyl-3H-benzo[e]1,2,4-thiadiazaperhydroine-1,1-dione, 2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, 2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione, 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, 2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide; 7-Chloro-3-methyl-3,4-dihydro-1lambda~6~,2,4-benzothiadiazine-1,1(2H)-dione
Storage Store at room temperature, tightly sealed, away from heat, light and moisture.
Solubility Soluble in DMSO
Organoleptic Profile White to off-white powder
Physical Form Solid
Specification ≥98%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

Lab Analysis

2303EURO.741E_IDRA 21 LOT= 230423
2301EURO.634A_IDRA CAS=22503-72-6