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NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo. Emerging evidence also indicates that NSI-189 phosphate has regionally specific effects insofar as neurogenesis is observed largely in the subventricular zone of the hippocampus. Results from a preliminary proof of concept study suggests that NSI-189 may be capable of mitigating depressive symptoms and improve cognitive function in adults with DSM-5-defined Major Depressive Disorder (MDD).
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| Size | 1g, 5g |
|---|
| Application | TBA |
| CAS | 1270138-40-3 |
| Molar Mass | 366.4998 g/mol |
| Chemical Formula | C22H30N4O1 |
| IUPAC Name | (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone |
| Synonyms | NSI-189, NSI189, NSI 189 |
| Storage | Room temperature |
| Solubility | Soluble in Ethanol |
| Organoleptic Profile | White crystalline powder |
| Physical Form | Solid |
| Specification | ≥98% |
